What Is This

What is this?

What Is This

This image illustrates the process of amyloid fiber formation via parallel stacking of monomeric protein units and oligomeric protein building blocks to elongated protein ‘strings’. Songi Han, her student Anna Pavlova, and coworkers are developing a generally applicable magnetic resonance tool to study the molecular basis of the early stages of protein aggregation occurring in situ. When protein-protein binding occurs, the surface hydration water at the interaction interface will be perturbed or excluded. Water is “squeezed out” at the interface whenever tight binding occurs, as detected by specifically tethered spin labels (shiny yellow dots).

A. Pavlova, E. R. McCarney, D. W. Peterson, F. W. Dahlquist, J. Lew, S. Han, Site-specific dynamic nuclear polarization of hydration water as a generally applicable approach to monitor protein aggregation, Phys. Chem. Chem. Phys (2009) in press.

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