What Is This

What is This?

What Is This

When large amounts of unfolded proteins accumulate in a yeast cell’s endoplasmic reticulum (ER), a response is activated, and a signal is transmitted from the ER to the nucleus via the membrane-spanning kinase Ire1p.

Professor Frank Doyle and chemical engineering graduate student Scott Hildebrandt are currently modeling the unfolded protein response mathematically using a systems biology approach.

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